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12th Annual Coalition for Global Hearing Health
January 20-22, 2022 • Fully Virtual
Coalition for Global Hearing Health 2022. Virtual Global Conference. 20 - 22 January 2022. 14h00 - 17h30 (CET)

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EFFECT OF ORALLY ADMINISTERED GPX MIMETIC TOWARDS GPX AND MDA BLOOD LEVEL AND OAEs RESULT IN ACOUSTIC TRAUMA RISK

EFFECT OF ORALLY ADMINISTERED GPX MIMETIC TOWARDS GPX AND MDA BLOOD LEVEL AND OAEs RESULT IN ACOUSTIC TRAUMA RISK Excessive noise exposure may cause oxidative stress to the inner ear structure, resulting in acoustic trauma (AT). Oxidative stress was characterized by increasing of MDA decreasing of GPx enzyme, and abnormal OAEs. Aim of this study was to determine the impact of GPx mimetic to GPx and MDA level in blood, also OAEs value on soldiers with risk of AT due to explosion of Howitzer 105 artillery weapon. The study used clinical trial pre and post design, randomized, double blind and placebo controlled, on 34 new recruit soldiers were trained to firing artillery weapon. Exposure group was given Ebselen SPI 1005 200mg, orally once daily, meanwhile control group was given sucrose. MDA and GPx level in blood and DPOAEs value was measured, before and after firing. The data was analyzed using NNT and significance value (p<0.05). The results of the study shown the number of AT risk in controle group based on DPOAEs test the controle group shown 47.1% abnormal, exposure group shown 100% normally, and this difference stastically significance (p<0.051). The group which was given Ebselen shown increasing 82.4% erythrocyte GPx level (NNT, 95%CI=1.889 [1.159-3.016]; p=0.004), shown increasing 88.2% plasma GPx level (NNT=1.417; p<0.001), decreasing 100% erythrocyte MDA level (NNT= 2.125; p=0.01), shown decreasing 94.1% plasma MDA level (NNT=2.125; p=0.01), and resulting 100% in normally DPOAEs value (NNT= 2.125; p=0.01). This study concluded that giving Ebselen SPI 1005 to soldiers with risk of AT, increasing GPx level in blood, decreasing MDA level in blood, and resulting normally DPOAEs. Keywords : Acoustic trauma (AT), Ebselen, GPx, MDA, Otoacoustic emission (OAEs).

  • GPX MIMETIC
  • GPX AND MDA BLOOD LEVEL AND OAEs RESULT
  • ACOUSTIC TRAUMA RISK

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Sigit Sasongko (POC,Primary Presenter), Medical Faculty of General Achmad Yani University / Dustira Army Hospital, sieragolftht@yahoo.com;
Dr. dr. Sigit Sasongko, Sp.THT-KL., M.Kes. Born in Probolinggo, East Java at 7th January 1966. First Son of three. Used to spend chilhood at East Java until married in 1991. Have two son, one as dentist and one as Employee in Private Departement. Start medical degree to general practitioner in Medical Faculty in Airlangga University 1984 until 1990. In 1991 Join military academy of indonesia as a military doctor until now. Then working in Dustira Army Hospital (West Java) 1991 - until now. Start Otorhinolaryngologist education at Padjadjaran University 1998-2003. Then P.H.D. at Padjadjaran University 2010-2015 about Otology Clinical Assesment. Now Dr. dr. Sigit Sasongko, Sp.THT-KL., M.Kes. work as Chief in ENT Departement in Dustira Army Hospital with Military state Liuetenant Colonel.
      ASHA DISCLOSURE:

Financial -

Nonfinancial -


      AAA DISCLOSURE:

Financial - No relevant financial relationship exists.